We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.
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Introduction to Food and Airborne Fungi. Spot map illustrating case-patient location on the northwestern wing of the eighth floor 8NE and the seventh floor 7NE from the left panel and outbreaks right panel at the time of case diagnosis.
Aspergillus Fungi described in Our investigation was limited by constraints in istus retrospective analyses. These cases illustrate the potential for uncommon species like A. Acknowledgments We thank Estella Whimbey and Nancy Whittington for their help with acquiring information on hospital airflow and construction activity, Robin Olsen for performing the environmental air sampling, Chris Davis for database support, David Madtes and Pat McDowell for obtaining bronchoscopic information, ustud S.
Aspergillus ustus Infections among Transplant Recipients
Dr Panackal received grant support from the John P. Sutus note, construction of a new surgery pavilion occurred outside our hospital building beginning in July and ending in December Pavie J, Lacroix C, Hermose DG Breakthrough disseminated Aspergillus ustus infection in allogeneic hematopoietic stem cell transplant recipients receiving voriconazole and caspofungin prophylaxis.
Fukuda T, Boeckh M, Carter RA Risks and outcomes of invasive fungal infections in recipients of sutus hematopoietic stem cell transplants after nonmyeloablative conditioning. These patients also possessed classic risk factors for IA in that most had graft-versus-host disease that required corticosteroid and other immunosuppressive therapy Epidemiologic Investigation Estimating that patients were admitted for HSCT during the at-risk period, the highest overall attack rate was 1.
Suggested citation for this article: Determining the source of infection is further complicated in that a combination of inoculum effect and aepergillus host immunosuppression make calculating the incubation period problematic. The species does not modify the pH of the medium final pH 6.
In the absence of substantial air disturbances, A. An attack rate was estimated among the usrus exposed HSCT patients using as the denominator the number of patients who were admitted for HSCT from July through October and March through Septemberthe at-risk periods when cases occurred.
Infections caused by A. The latter was included solely as an outbreak, unrelated control to evaluate the discriminatory power of the molecular typing method employed in the analysis of the ophthalmic strains.
Based on the clustering of cases in space and time and molecular data, common-source acquisition of this unusual drug-resistant species is possible.
J Am Acad Dermatol. Fever, chills, and dyspnea, pulmonary consolidation. N Engl J Med. It is a reference species for the standard NF X Antifungal drug susceptibility testing of A.
Aspergillus ustus | Aspergillus & Aspergillosis Website
Although we do not know breakpoints of A. The strain from the pediatric patient differed from the ophthalmic isolates in five electrophoretic loci.
Molecular typing by using randomly amplified polymorphic DNA RAPD and antifungal drug susceptibility testing were performed on clinical and environmental isolates recovered from our hospital from to It is moss-green on all studied materials.
Fever, chest pain, nodular pulmonary opacity. Of note, the lung transplant patient appeared to be colonized with a strain of A. Rheumatic heart disease, prosthetic valve replacement. Curr Infect Dis Rep. Construction, a well-known environmental risk factor for IA 36was ongoing outside the hospital during the time of these outbreaks.
Clinical isolates exhibited decreased susceptibility to antifungal drugs, especially azoles.
However, the true incidence of A. Support Center Support Center.
Similarly, the isolate from asprrgillus 1 was genetically most similar to that of patient 4; patients 1 and 4 resided in adjacent rooms, also separated by a period of 2 years. The second occurred from March to September 1 proven skin infection [likely disseminated from lung] and 2 probable lung infections: The isolate from patient 3 was not viable on subculturing and, as such, was not available for molecular analysis.