Geomatrix technology (Jago Pharma, Muttenz, Switzerland) can control release of one or more drugs from a tablet containing different drugs in different layers. Download/Embed scientific diagram | Geomatrix Technology: two-and three-layer systems. from publication: Development of Controlled Release Three-layered. Geomatrix is the smartest solution to grow your retail sales, available in 67 countries. We integrate best official data and technologies in a single platform.

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The mini-tablets were compressed within an outer filling that was composed of MC Avicel PH that filled the space between the minitablets, this outer filling provided rapid drug release while the minitablets provided prolonged release [ 88 ].

The tablet demonstrated success in delivering nifedipine at a relatively constant rate for 24 hours [ 94 ]. It consists of a hydrophilic matrix core, containing the active ingredient and one or two impermeable or semi-permeable polymeric coatings are applied on the core.

These geometric manipulations may also be employed to develop drug delivery systems for the treatment of specialized biological conditions where zero-order drug release is not optimal, for example chronotherapy for heart conditions [ 46 ] or the scheduled treatment of asthma and inflammation [ 47 ]. It has been shown that the combination hechnology these two drugs results in an important reduction of low density lipoprotein cholesterol as well as desirable variations in high density lipoprotein cholesterol [ 83 ].

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Post a comment Name The concave and convex bases themselves exhibited different release patterns, with the convex base releasing drug faster [ 47 ]. Compressed donut-shaped tablets with zero-order release kinetics. With press coating, there are no specific coating solvents or equipment that is needed and therefore the manufacturing process is more efficient [ 90 ]. The final segment consisted of an external coat that was comprised of PVP and PEG and a second therapeutic agent that would be immediately released.

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Another patent by Zerbe and co-workers presented a multilayer triple-layered oral system that had a matrix core that contained geomatrid NSAID for sustained release and two surrounding layers each containing an H 2 -receptor antagonist. The tablet was developed for the delivery of atenolol and sodium chloride and was used as an osmotic agent.

Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery

The proposed mechanism for the zero-order drug release from the first type of matrix was that as the hydrophilic barriers swelled and eroded, geojatrix rate of diffusion of drug from the hydrophobic middle layer decreased [ 6577 ].

Abstract Recent pharmaceutical research has focused on controlled drug delivery having an advantage over conventional methods.

Coupling of diffusion and relaxation. Polymeric materials play an important role in the functioning of these systems. Bimodal drug release may be advantageous in that the initial rapid release phase which is followed by a slow release phase is able to compensate for the slow absorption of drug from the stomach and small intestine.

Design and evaluation of transdermal drug delivery of ketotifen fumarate. The system consisted of a disc-shaped matrix core that was compression-coated on one surface as well as at the circumference in order to form a cup around the core. Conclusions It has been elucidated that geometrically altered drug delivery systems, especially multilayered tablets, have provided various advantages to drug delivery technology.

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The hydrochloride salts of weakly basic drugs had a slower release rate than neutral drugs [ 66 ]. The elementary module depicted in Figure 12a is a swellable matrix device comprising of a heomatrix base on one end and a convex base on the other end.

A novel colonic drug delivery system of ibuprofen. If more than one drug is incorporated, there is no way of avoiding chemical incompatibilities. Polymers technologyy sustained macromolecule release: The release rate from these formulations enabled a twice daily administration of the delivery system [ 92 ]. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license http: The core contains the active ingredient and the combination of barrier layers control the surface area diffusion of the drug out of the core.

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SkypePharma [ 85 ]. Intraoperative therapy with liposomal drug delivery: Zero-order release was achieved when the slowly erodible polymers were used and parabolic drug release was achieved when rapidly erodible polymers were used when diltiazem hydrochloride was incorporated as a model drug. The earlier described studies have provided practical technical ideas in the development of multilayered tablets depending on the clinical applications of these systems.

Transport mechanisms and device design. Study showed that the addition of the drug-free layer, its composition and thickness could change the release profile [19].

Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery

Press coating is a good technique for producing this type of time-dependent release. The way forward in the new decade. They found that covering a larger area of the core tablet by a barrier layer results in the retardation of drug release to a greater extent, as it forms a more efficient barrier thereby decreasing the drug release rate [ 40 ].

A study that was conducted by Fassihi tecbnology co-workers investigated zero-order release kinetics from a self-correcting floatable asymmetric configuration drug delivery system. Comparative evaluation of various structures in polymer controlled drug delivery systems and the effect of their morphology and characteristics on drug release.